In 2008, Mdee worked with the Staying Alive Foundation on a project close to her heart. She got to visit the Uwanja wa Fisi with then-Staying Alive Foundation Special Ambassador Kelly Rowland. Mdee also joined Malaria No More in their Z!nduka Campaign, a campaign aimed at the eradication of malaria.
She was MTV’s voice at the 2011 UNAIDS Mali Youth Summit in Bamako and the subsequent High Level meeting in Cape Town, South Africa, She participated in the International Conference on HIV and STI’s in Addis Ababa, Ethiopia, and cofounded (along with M. K. Asante) STANDWIDTH, under the UNAIDS umbrella.
In 2012 Mdee hosted MTV Base Meets, a show geared towards empowering young Africans from around the world by giving them the rare opportunity to sit down with an influential leader. MTV Base Meets brought her in the company of Russell Simmons, Alek Wek, former President of Nigeria Hon. Olusegun Obasanjo, football star Emmanuel Adebayor and Akon. Still in 2012 Vanessa was awarded by the GAVI Alliance for her support in the initiation of free vaccinations for Tanzanian children.
In May 2013, Mdee was invited to speak at the World Economic Forum for Africa in Cape Town, South Africa on behalf of the GAVI Alliance on the announcement of the new record low price for the Human Papillomavirus (HPV) vaccines. Later that same month, Mdee again spoke on cervical cancer at the Global Forum for Cervical Cancer Prevention in Kuala Lumpur, Malaysia on behalf of Global Health Strategies. Mdee officially became a GAVI Ambassador and an active voice against cervical cancer.
Vanessa Mdee joins forces with arguably seven of Africa’s most popular songstresses for ONE mission and ONE mission only… Celebrating girl power on “Strong Girl” featuring Victoria Kimani (Kenya), Judith Sephuma (South Africa), Waje (Nigeria), Arielle T (Gabon), Gabriela (Mozambique), Yemi Alade (Nigeria), Selomor Mtukudzi (Zimbabwe) and Blessing Nwafor. The campaign has a petition which is calling on world leaders to track the fight against inequality and injustice by investing more in women and girls if the world is to end extreme poverty by 2030.